Tuesday, November 21, 2017

Propolis May Help Protect Against Radiation Damage

Radio-Modulatory Potential ofCaffeic Acid Phenethyl Ester: A Therapeutic Perspective

Anticancer Agents Med Chem. 2017 Nov 13

Use of natural agents is an upcoming area of research in cancer biology. Caffeic acid phenethyl ester has received great attention because of its therapeutic potential in various conditions including cancer. It is an active/abundant component of propolis. Propolis is a honey bee hive product produced by bees using their enzyme-rich digestive secretions on resinous mix, bee wax and pollen from plants. It is used to protect the beehive against bacteria and other infections.Although a lot of work has been done on chemotherapeutic aspects of CAPE, its role as a radiomodulator is yet to be delineated. It can act both as radioprotector and radiosensitizer. Depending on the tissue type it can modulate the radiation response by following different mechanisms.

This review will focus on the differential radiomodulatory effects of Caffeic Acid Phenethyl Ester in normal and cancer cells.Besides chemistry and bioavailability,it's potential as a therapeutic agent against radiation induced damage will also be discussed.

Monday, November 20, 2017

Propolis: This Bee Product is a Powerful Natural Immune Booster

By: Jordyn Cormier, November 19, 2017

Cold and flu season is in full swing, which means it’s time to start bringing on immune boosters again. Some of us will chug freshly squeezed orange juice. Others will slam shots of elderberry kombucha. A few will start force-feeding themselves and their family pungent raw garlic, all in a martyrish effort to avoid getting sick. But there is probably something even more powerful missing from your natural immune defense arsenal…propolis.

Propolis is one of the most undervalued natural immune boosters out there. Personally, I use my propolis spray daily. After years of getting sick every cold/flu season, a friend sent me some propolis to try. Ever since then, even the most inevitable colds seem to repel off of me. It’s pretty amazing.

If you are unfamiliar with propolis, it is a bee product, much like honey is—but that’s where the similarities end. Bees use propolis to keep their hives free of invaders and disease. It lines the hive walls and acts essentially as the immune system of the hive. And guess what—it can do the same for your body...

Sunday, November 19, 2017

Turkish Honeys Beat Manuka Antibacterial Properties

Turkish honey beats world famous Manuka honey, study finds


The flower honey from Turkey's southeastern province of Hakkari has much higher antimicrobial capabilities compared to the world famous Manuka honey of Australia and New Zealand, a new study has found.

Sevgi Kolaylı, a chemistry professor at the Karadeniz Technical University in Trabzon, says her recent study has found that several kinds of honey gathered from different parts of Turkey showed much higher antimicrobial activity compared to Manuka honey.

Kolaylı's study found that antimicrobial activities, which makes honey act against bacteria like antibiotics, are significantly higher in flower honey from Hakkari province compared to Manuka.

Several kinds of Turkish chestnut and oak honey also showed higher antibacterial properties, Kolaylı said.

The professor also said that Turkey ranks only behind China and Argentina as the world's top honey producing country.

"Antioxidant properties are richer in dark colored honey, whereas antimicrobial activities are higher in lighter colored honey," the professor explained, and added that Turkey is home to rich honey from both spectrums.

Saturday, November 18, 2017

Ethanolic Extract of Polish Propolis Boosts Oral Hygiene

The Influence of Toothpaste Containing Australian Melaleuca alternifolia Oil and Ethanolic Extract of Polish Propolis on Oral Hygiene and Microbiome in Patients Requiring Conservative Procedures

Molecules. 2017 Nov 13;22(11). pii: E1957

The study was based on the use of a toothpaste with antiphlogistic activity, containing Australian Melaleuca alternifolia oil (tea tree oil-TTO) and ethanolic extract of Polish propolis (EEP). Fifty-one patients with varying conditions of the gingiva were divided into two groups.

The study group received the toothpaste with TTO and EEP, while the control group received the same toothpaste but without TTO and EEP. Approximal plaque index (API), simplified oral hygiene index (OHI-s) and modified sulcus bleeding index (mSBI) were assessed in three subsequent stages. During each examination, swabs were employed for microbiological inoculation. During the period of use of toothpastes with TTO and EEP, a significant reduction of the API was observed, as assessed upon the control visit after 7 days and after 28 days, compared to baseline. A statistically significant reduction of mSBI was observed after 7 and 28 days of using the toothpaste with TTO and EEP, as compared to the value upon the initial visit. Statistically significant differences in the OHI-s value were observed in the study group, which was using the active toothpaste. The use of a toothpaste containing TTO and EEP helps to maintain microbiome balance.

The observed stabilisation of bacterial microflora confirms the beneficial activity of toothpaste containing EEP and TTO compared to the control group, where the lack of these substances contributed to the emergence of qualitative and quantitative changes in oral microbiome.

Honey: A Therapeutic Agent for Disorders of the Skin

Cent Asian J Glob Health. 5(1):241

Problems with conventional treatments for a range of dermatological disorders have led scientists to search for new compounds of therapeutic value. Efforts have included the evaluation of natural products such as honey. Manuka honey, for example, has been scientifically recognised for its anti-microbial and wound healing properties and is now used clinically as a topical treatment for wound infections. In this review, scientific evidence for the effectiveness of honey in the treatment of wounds and other skin conditions is evaluated. A plethora of in vitro studies have revealed that honeys from all over the world have potent antimicrobial activity against skin relevant microbes. Moreover, a number of in vitro studies suggest that honey is able to modulate the skin immune system.

Clinical research has shown honey to be efficacious in promoting the healing of partial thickness burn wounds while its effectiveness in the treatment of non-burn acute wounds and chronic wounds is conflicted. Published research investigating the efficacy of honey in the treatment of other types of skin disorders is limited. Nevertheless, positive effects have been reported, for example, kanuka honey from New Zealand was shown to have therapeutic value in the treatment of rosacea. Anti-carcinogenic effects of honey have also been observed in vitro and in a murine model of melanoma.

It can be concluded that honey is a biologically active and clinically interesting substance but more research is necessary for a comprehensive understanding of its medicinal value in dermatology.

Friday, November 17, 2017

Powder Containing Extract of Green and Red Propolis a Possible Antimicrobial Agent

Evaluation of the antimicrobial activity and cytotoxic effect of hydroxyapatite containing Brazilian propolis

Biomed Mater. 2017 Nov 14

The aim of this work was to produce hydroxyapatite powder (HA) containing dry extract of green and red propolis, and to evaluate possible bactericidal activity of the materials in a short period of time through a fast release system.

The ethanolic extracts of green and red propolis (EEP) were incorporated into the material by spray drying. After release tests, powders containing dry EEP were characterized regarding the content of total phenolics and flavonoids. Materials characterization was made by scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR). The antimicrobial activity was evaluated by plate colony counting, minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) against Staphylococcus aureus (S. aureus). The cytotoxicity of the materials was determined by the neutral red incorporation method. Materials showed apparently spherical morphology, indicating a decrease in the agglomeration degree with the propolis addition.

HA and propolis characteristic functional groups were observed in FTIR. Materials had higher release of phenolics and lesser amounts of flavonoids when compared to the EEP, with the higher amounts of flavonoids observed for HA with red propolis. The bactericidal effect for all materials was observed within the interval of 0.5 to 1 hour. All materials showed lesser inhibitory activity (MIC) and higher bactericidal activity (MBC) when compared to the EEP, with the best results attributed to HA with red propolis. The values of IC50 (concentration needed to inhibit 50% of the cell growth) obtained from the cytotoxicity assay for HA with green and red propolis lied between MIC and MCB.

Considering these results, it is suggested that HA with propolis may be used as a possible antimicrobial agent, inhibiting the growth of S. aureus, despite further in vivo biocompatibility should be investigated before using this material as a medical device with bactericidal potential.

Thursday, November 16, 2017

Ginger and Propolis Exert Neuroprotective Effects

Ginger and Propolis Exert Neuroprotective Effects against Monosodium Glutamate-Induced Neurotoxicity in Rats

Molecules. 2017 Nov 8;22(11). pii: E1928

Central nervous system cytotoxicity is linked to neurodegenerative disorders. The objective of the study was to investigate whether monosodium glutamate (MSG) neurotoxicity can be reversed by natural products, such as ginger or propolis, in male rats.

Four different groups of Wistar rats were utilized in the study. Group A served as a normal control, whereas group B was orally administered with MSG (100 mg/kg body weight, via oral gavage). Two additional groups, C and D, were given MSG as group B along with oral dose (500 mg/kg body weight) of either ginger or propolis (600 mg/kg body weight) once a day for two months. At the end, the rats were sacrificed, and the brain tissue was excised and levels of neurotransmitters, ß-amyloid, and DNA oxidative marker 8-OHdG were estimated in the brain homogenates. Further, formalin-fixed and paraffin-embedded brain sections were used for histopathological evaluation.

The results showed that MSG increased lipid peroxidation, nitric oxide, neurotransmitters, and 8-OHdG as well as registered an accumulation of ß-amyloid peptides compared to normal control rats. Moreover, significant depletions of glutathione, superoxide dismutase, and catalase as well as histopathological alterations in the brain tissue of MSG-treated rats were noticed in comparison with the normal control. In contrast, treatment with ginger greatly attenuated the neurotoxic effects of MSG through suppression of 8-OHdG and β-amyloid accumulation as well as alteration of neurotransmitter levels.

Further improvements were also noticed based on histological alterations and reduction of neurodegeneration in the brain tissue. A modest inhibition of the neurodegenerative markers was observed by propolis.

The study clearly indicates a neuroprotective effect of ginger and propolis against MSG-induced neurodegenerative disorders and these beneficial effects could be attributed to the polyphenolic compounds present in these natural products.

Wednesday, November 15, 2017

Antimicrobial Effect of Ginger, Garlic, Honey, and Lemon Extracts on Streptococcus mutans

J Contemp Dent Pract. 2017 Nov 1;18(11):1004-1008.

The aim of this study was to evaluate the effect of lemon, ginger, garlic, and honey extracts on Streptococcus mutans.


Commercially obtained honey, ginger, garlic, and lemon were included in the study to evaluate its efficacy in isolation and in combination against S. mutans. The efficacies of extracts were tested using well diffusion method, and its effect was evaluated by measuring the zone of inhibition around the well. Antimicrobial activity of the extracts was carried out individually and compared considering triplicates of all the extracts.


When individual comparison of the extracts was made, garlic showed greatest antimicrobial activity with a mean zone of inhibition (34.9 ± 0.58 mm) and honey showed least antimicrobial activity (0.5 ± 0.6 mm). When combinations of extracts were tested against S. mutans, lemon and garlic combination showed the greatest zone of inhibition (27.6 ± 0.43 mm) compared with other combinations, and ginger + lemon combinations showed the least zone of inhibition (12.6 ± 0.43 mm).


This study concluded that garlic showed a greatest antimicrobial effect against S. mutans when compared with other preparations individually and garlic and lemon showed greatest zone of inhibition in combination than other preparations.


Antibiotics and other chemical agents are mainly used to treat the common dental infections. However, due to the excessive use, it can result in antibiotic resistance. Hence, herbal medicines with medicinal values should be replaced with conventional methods.

Tuesday, November 14, 2017

Honey Polyphenols May Help Treat Cardiovascular Diseases, Diabetes, Cancer, and Neurodegenerative Disorders

Beneficial roles of honey polyphenols against some human degenerative diseases: A review

Pharmacol Rep. 2017 Jul 4;69(6):1194-1205

Honey contains many active constituents and antioxidants such as polyphenols. Polyphenols are phytochemicals, a generic term for the several thousand plant-based molecules with antioxidant properties.

Many in vitro studies in human cell cultures as well as many animal studies confirm the protective effect of polyphenols on a number of diseases such as cardiovascular diseases (CVD), diabetes, cancer, neurodegenerative diseases, pulmonary diseases, liver diseases and so on. Nevertheless, it is challenging to identify the specific biological mechanism underlying individual polyphenols and to determine how polyphenols impact human health. To date, several studies have attempted to elucidate the molecular pathway for specific polyphenols acting against particular diseases.

In this review, we report on the various polyphenols present in different types of honey according to their classification, source, and specific functions and discuss several of the honey polyphenols with the most therapeutic potential to exert an effect on the various pathologies of some major diseases including CVD, diabetes, cancer, and neurodegenerative diseases.

Monday, November 13, 2017

Royal Jelly as Skin Moisturizing Agent

10-Hydroxy-2-Decenoic Acid in Royal Jelly Extract Induced Both Filaggrin and Amino Acid in a Cultured Human Three-Dimensional Epidermis Model

Cosmetics 2017, 4(4), 48

Royal jelly (RJ) is a natural product which the honeybee secretes as a special diet for a queen bee. It is one of the natural products in which various functionalities, such as antibacterial effects, immunomodulating properties, and estrogen-like action, were reported.

We investigated the effect of the RJ extract on the moisturizing effect by topical application in humans. The stratum corneum moisture was increased significantly after four weeks by using the RJ extract lotion compared to placebo lotion. RJ extract contained a characteristic ingredient, 10-hydroxy-2-decenoic acid (10H2DA) and 10-hydroxydecanoic acid (10HDAA), etc. However, the mechanism of stratum corneum moisture and its contributing ingredient have not yet been elucidated.

We have investigated the effects of 10H2DA and 10HDAA on the free amino acids content in the stratum corneum using a cultured human three-dimensional epidermis model. Additionally, the effect of 10H2DA and 10HDAA on the amounts of filaggrin (FLG) and aquaporin 3 (AQP3) were investigated at the mRNA level and by immunohistochemistry using a cultured human epidermis model. It was determined that 10H2DA increases the free amino acids in the stratum corneum of the cultured human epidermis model, and that it increased FLG on both the mRNA and protein levels. On the other hand, these actions are not observed by treatment of 10HDAA. The mRNA and protein level of AQP3 did not increase with 10H2DA or 10HDAA use.

It was thought that the increase in the amount of FLG and the increase in the free amino acids of the epidermis and the stratum corneum, respectively, by 10H2DA were participating in the moisturizing function of the stratum corneum by the continuous use of RJ extract lotion.

Sunday, November 12, 2017

New Product Uses Propolis, Bee Venom, Wax Moth Extract to Treat Joint and Tissue Pain

SustaFix LLC Created a Honey-Based Product for Treating Joint and Tissue Pain

November 10, 2017 --(PR.com)-- A novel honey-based product for treating joint and tisssue pain has been created and manufactured in Atlanta, Georgia. SustaFix gel contains propolis extract, bee venom, bee extract, beeswax, cedar sap, olive oil, horse chestnut extract and wax moth extract. Additional ingredients embaded in product's formula include vitamins C, B1, and B5, which play role in strengthening the vein muscle walls and tissue regeneration. Other ingredients include substances that possess vasodilatory and painkilling properties. SustaFix's action is pointed at relieving the inflammation, eliminating pain and swelling of joints, and repressing the symptoms of arthritis and arthrosis.

The use of honey for medical purposes is known for decades as alternative or complementary medicine. Today it is gaining popularity not only in the United States, but Europe and Asia as well. According to a research, made by National Center for Complementary and Alternative Medicine in 2007 (https://nccih.nih.gov/sites/nccam.nih.gov/files/camuse.pdf), almost 40 percent of adults in America use some form of alternative medicine. It is known that honey is widely used in treating a variety of medical conditions, including arthritis, joint a, promotes burn and wound healing, and helps in suppressing cough.

SustaFix beeswax gel smooth consistency makes it easily applicable on the affected areas. A small amount of the gel should be spread on the area of concern and then - gently massaged until its full absorption. Tube contains 100 ml substance, that should be applied once or twice a day depending on the severity of the condition.

Saturday, November 11, 2017

Propolis Prevents Biodegradation of Natural Rubber

Propolis as an antidegradant and biocidal agent for natural rubber

Journal of Applied Polymer Science

First published: 7 November 2017

The numerous applications of polymers in many areas of our lives make it necessary to protect them from aging. Increases in the safety and time of polymer material exploitation demands the application of antidegradants with broad scopes of action.

In this study, crude propolis, originating from two geographical regions of Poland, was used to protect peroxide-cured natural-rubber vulcanizates filled with silica or carbon black from degradation by oxygen, ozone, and microorganisms. Thermogravimetry analysis confirmed the stability of propolis under the curing conditions. From vulcametric torque measurements and determinations of the mechanical properties, we determined that the incorporation of propolis did not adversely affect the performance of the natural-rubber vulcanizates.

The addition of propolis to the rubber mix made the vulcanizates resistant to thermooxidative and ozone aging and protected them from biodegradation in soil and the action of microorganisms.

Friday, November 10, 2017

Bee Venom Acupuncture Helps Treat Lower Back Pain

Efficacy of Bee Venom Acupuncture for Chronic Low Back Pain: A Randomized, Double-Blinded, Sham-Controlled Trial

Toxins 2017, 9(11), 361

Bee venom acupuncture (BVA) is an effective treatment for chronic low back pain (CLBP) through the pharmacological effects of bee venom and the simultaneous stimulation of acupoints. However, evidence of its efficacy and safety in humans remains unclear.

Using a double-blind, randomized study, 54 patients with non-specific CLBP were assigned to the BVA and sham groups. All participants underwent six sessions of real or sham BVA for 3 weeks, in addition to administration of 180 mg of loxonin per day. The primary outcome, that is, “bothersomeness” derived from back pain, was assessed using the visual analog scale. Secondary outcomes included pain intensity, dysfunction related to back pain (Oswestry Disability Index), quality of life (EuroQol 5-Dimension), and depressive mood (Beck’s depression inventory). Outcomes were evaluated every week during the treatment period and followed up at weeks 4, 8, and 12.

After 3 weeks of the treatment, significant improvements were observed in the bothersomeness, pain intensity, and functional status in the BVA group compared with the sham group. Although minimal adverse events were observed in both groups, subsequent recovery was achieved without treatment.

Consequently, our results suggest that it can be used along with conventional pharmacological therapies for the treatment of CLBP.

Thursday, November 09, 2017

Charles Mraz Apitherapy Course and Conference (CMACC)

Theory In Practice, A Hands-On Approach

November 10-12 2017

The Redondo Beach Hotel

400 N. Harbor Drive

Redondo Beach, CA 90277


Bee Venom Component May Help Treat Hepatitis B

Medical Express, 11/7/2017

"We now have a drug that can knock down hepatitis B surface antigen and determine whether or not we can actually cure people with that," Dr. Lanford said.

The drug is delivered by subcutaneous (under the skin) injection. Scientists designed a molecule that delivers the medicine directly to the liver where it binds to a receptor. Then, another molecule that's derived from bee venom, helps break through membranes in the liver cells to deliver the medicine directly into the cytoplasm of the cells where it takes effect. The siRNA interferes with the expression of the HBV messenger RNA that produces the surface antigen...