Monday, December 11, 2017

Royal Jelly May May Be a Treatment for Alzheimer’s Disease, Colitis, Crohn’s Disease, Menopausal Symptoms, Diabetes, Osteoporosis


10 Health Benefits of Royal Jelly and Why It May Be A Treatment for Alzheimer’s Disease

By Kaitlin Covel Dec 9 2017

Royal Jelly is not the magic pill cure-all of the natural world, but the incredible health benefits do give it an almost miraculous reputation considering that scientific studies testify to its potential to positively treat a variety of illnesses and symptoms including that of Alzheimer’s Disease.
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What is royal jelly you ask? Royal jelly is the substance milked from the jaws of nurse bees in the hive exclusively for the queen bee. Royal jelly contains significant amounts of protein that are important for cell growth and reproduction as well as carbohydrates, fats, free amino acids, vitamins and minerals. It is interesting to note that royal jelly is rich in B vitamins, the 8 amino acids humans cannot produce, and potassium, magnesium, calcium, copper, sulfur, zinc, iron and manganese as well. No wonder royal jelly is considered a wellspring of nutrients. Here are the top 10 health benefits of royal jelly:

1. Alzheimer’s Disease Treatment

Research conducted recently demonstrated that royal jelly benefits neural function which indicates that it may improve short-term memory for patients with Alzheimer’s disease. The study was published in Advanced Biomedical Research. The powerful antioxidants in Royal Jelly make it an effective and natural treatment for fighting free radical attacks and oxidative stress which occur in many neurodegenerative diseases like Alzheimer’s disease.

2. Immune System Modulator

According to research published in a 2001 study in the journal International Immunopharmacology, royal jelly can boost the functions of the immune system. Histamine responses to allergens were suppressed immediately, evidencing that it may help to relieve allergies of a seasonal nature. Hopefully more research will be completed to validate royal jelly’s usefulness in treating allergies.

3. Colitis, Crohn’s Disease, and IBS Treatment

A European study found that royal jelly protected the mucosa of the colon by limiting the negative effects of the acidic substance that was given to the rats with colitis. Another finding in the study was that royal jelly protected against erosion of the cells in the colon. To replicate the results of this study in humans, the researchers concluded that a 140 pound person would need to take approximately 10 grams of royal jelly per day. In order to get this amount, a freeze-dried dose of royal jelly would be about 2 teaspoons and a fresh dose would be about 2 tablespoons....

Sunday, December 10, 2017

Hydrophilic Bioactive Components of Greek Royal Jelly

Targeted profiling of hydrophilic constituents of royal jelly by hydrophilic interaction liquid chromatography-tandem mass spectrometry

J Chromatogr A. 2017 Nov 13. pii: S0021-9673(17)31667-9

In the present work a Hydrophilic Interaction Liquid Chromatography-tandem Mass Spectrometry (HILIC-MS/MS) method was developed for the efficient separation and quantification of a large number of small polar bioactive molecules in Royal Jelly.

The method was validated and provided satisfactory detection sensitivity for 88 components. Quantification was proven to be precise for 64 components exhibiting good linearity, recoveries R% > 90% for the majority of analytes and intra- and inter-day precision from 0.14 to 20% RSD.

Analysis of 125 fresh royal jelly samples of Greek origin provided useful information on royal jelly's components revealing lysine, ribose, proline, melezitose and glutamic acid to be in high abundance. In addition the occurrence of 18 hydrophilic nutrients which have not been reported previously as royal jelly constituents is shown.

Saturday, December 09, 2017

Indian Propolis Shows Anti-Cancer Effect

Standardization, chemical profiling, in vitro cytotoxic effects, in vivo anti-carcinogenic potential and biosafety profile of Indian propolis

J Ayurveda Integr Med. 2017 Dec 4. pii: S0975-9476(17)30185-7

BACKGROUND:

Propolis from apiculture is known for wide range of medicinal properties owing to its vast chemical constituents including polyphenols, flavonoids and anticancer agent Caffeic acid phenethyl ester (CAPE).

OBJECTIVES:

The objective of the study was to extract and standardize Indian propolis (IP) with respect to selected markers by newly developed High performance liquid chromatography (HPLC) method, to evaluate in vitro and in vivo anticancer activity and biosafety of Indian propolis.

MATERIALS AND METHODS:

IP was extracted, optimized and standardized using a newly developed and validated HPLC method for simultaneous estimation of caffeic acid, apigenin, quercetin and CAPE. The standardised ethanolic extract of IP (EEIP) was screened for in vitro cytotoxicity using sulforhodamine B (SRB) assay, in vivo anti-carcinogenic effect against Dalton's Lymphoma ascites (DLA) cells, hemolytic effect and pesticide analysis.

RESULTS:

The EEIP was found to contain more amount of total flavonoids (23.61+ 0.0452 mg equivalent of quercetin/g), total polyphenolics (34.82 + 0.0785 mg equivalent of gallic acid/g) and all selected markers except caffeic acid compared to all other extracts. EEIP showed better anti-cancer potential than CAPE on MCF-7 and HT-29 cell line and significant (p < 0.01) in vivo anti-carcinogenic effects against DLA in comparison with 5-fluorouracil. EEIP was found to be non-hemolytic.

CONCLUSION:

From in vitro cytotoxicity, in vivo anti-carcinogenicity and biosafety studies it can be concluded that the standardized EEIP is safe and can be considered for further development as a biomedicine.

Friday, December 08, 2017

Manuka Honey Helps Treat Severe Atopic Eczematous Dermatitis

Manuka Honey: A Case Study of Severe Atopic Eczematous Dermatitis Reaction to Henna Tattoo

Plast Surg Nurs. 2017 Oct/Dec;37(4):154-157

Many mainstream medications were derived from plants and originally utilized in patient management well prior to the extensive research and testing processes of current pharmaceutical standards. The evolution of therapeutic management within the pharmaceutical and skin care industry often uses synthetic processing of products with less of a focus on the natural ingredients from which they were originally derived.

However, more recently there has been a shift in pharmacological management to include the therapeutic use of more holistic medicines and practices and thus a broadening of the uses of nontraditional medical treatment options. This has been seen in the use of treatments, such as Manuka honey, for skin conditions and dermal injuries. It is often with off-label uses, or conditions resistant to other treatments, that then prompt the use of holistic products and the true value of the product is validated.

As with the following case study, the example of the use of Manuka honey on a severe atopic contact dermatitis eczematous reaction provides further documentation and supportive evidence of the potential efficacy of the properties of this particular natural product.

Thursday, December 07, 2017

Propolis Component Useful in Treatment of Acute Lung Injury

Discovery of caffeic acid phenethyl ester derivatives as novel myeloid differentiation protein 2 inhibitors for treatment of acute lung injury

Eur J Med Chem. 2017 Dec 1;143:361-375

Myeloid differentiation protein 2 (MD2) is an essential molecule which recognizes lipopolysaccharide (LPS), leading to initiation of inflammation through the activation of Toll-like receptor 4 (TLR4) signaling. Caffeic acid phenethyl ester (CAPE) from propolis of honeybee hives could interfere interactions between LPS and the TLR4/MD2 complex, and thereby has promising anti-inflammatory properties.

In this study, we designed and synthesized 48 CAPE derivatives and evaluated their anti-inflammatory activities in mouse primary peritoneal macrophages (MPMs) activated by LPS. The most active compound, 10s, was found to bind with MD2 with high affinity, which prevented formation of the LPS/MD2/TLR4 complex. The binding mode of 10s revealed that the major interactions with MD2 were established via two key hydrogen bonds and hydrophobic interactions. Furthermore, 10s showed remarkable protective effects against LPS-caused ALI (acute lung injury) in vivo.

Taken together, this work provides new lead structures and candidates as MD2 inhibitors for the development of anti-inflammatory drugs.

Wednesday, December 06, 2017

Honey Effective as Treatment for Chemotherapy-Induced Mucositis in Paediatric Oncology Patients

Global Health Journal Club: Is Honey Effective as a Treatment for Chemotherapy-induced Mucositis in Paediatric Oncology Patients?

J Trop Pediatr. 2017 Nov 30

Oral mucositis (OM) is an inflammatory response of mucosal epithelium to the cytotoxic effects of chemotherapy and radiotherapy causing severe oral pain and ulceration, which may complicate the management of cancer. The Mucositis Prevention Guideline Development Group has developed an international guideline for the prevention of mucositis in children receiving treatment for cancer or undergoing haematopoietic stem cell transplantation.

Evidence-based preventative strategies include cryotherapy, low-level light therapy and keratinocyte growth factor. However, these strategies are often not available in resource-poor settings. There is some evidence that honey may be a suitable treatment for OM in adult patients. We performed a literature search of 11 databases to find papers exploring the use of honey to treat chemotherapy-associated mucositis in paediatric oncology patients.

We found four papers, which provide Grade C evidence that honey is effective as a preventative and therapeutic measure for OM in paediatric oncology patients.

Monday, December 04, 2017

Give Children Honey and Lemon, Not Cough Medicine Says Top Doc

By Henry Bodkin, 1 December 2017 

Children should not be given cough medicine but should instead be treated with “old fashioned” honey and lemon, a leading paediatrician has said.

Using over-the-counter syrups and medications risk unintentionally overdosing toddlers and causing “toxic” events, according to Dr Oliver Bevington, from the Royal College of Paediatrics and Child Health.

Chair of the college’s trainees’ committee, Dr Bovington said there was no evidence cough medicines work and added they can end “actually end up doing more harm than good”.

Most childhood coughs and colds get better simply with rest, fluids and possibly paracetamol or ibuprofen, he said.

The intervention follows an announcement by the NHS earlier this year saying it would no longer fund free cough mixture.

“A lot of cough and cold medicines contain active ingredients such as nasal decongestants, antihistamines and cough suppressors that may, in large doses, have adverse effects or be toxic if consumed in large quantities, particularly to the under-sixes who are much more susceptible,” he said.

“The bottom line is there is absolutely no evidence that cough medicines work as there has been very little research with regards to their use and, potentially, they could actually do children more harm than good.

“My advice for parents would be to stick to old fashioned honey and lemon.”...

Sunday, December 03, 2017

Bee Venom Component Inhibits Tumor Growth

The anti-hepatocellular carcinoma activity of Mel-P15 is mediated by natural killer cells

Oncol Lett. 2017 Dec;14(6):6901-6906

Mel-P15 is a peptide derived from melittin, the main toxic component in the venom of the European honeybee Apis mellifera.

In the present study, the antitumor effects of Mel-P15 and the underlying molecular mechanisms of these effects in vivo were investigated. Mel-P15 directly stimulated natural killer (NK) cell cytotoxicity in vitro, which was increased to 55.45% at a 4 µg/ml dose of Mel-P15. In the mouse liver cancer (H22) xenograft mice model, Mel-P15 suppressed tumor growth in vivo; the tumor inhibitory rate was 61.15% following treatment with 2 mg/kg Mel-P15. In addition, the immune response was activated following Mel-P15 treatment. Mel-P15 treatment increased the spleen and thymus indices, promoted splenocyte proliferation, stimulated NK cytotoxicity and upregulated the secretion of cytokines, including interleukin-2, interferon-γ and tumor necrosis factor-α. In addition, the tumor inhibitory effect of Mel-P15 on BEL-7402-bearing nude mice was abrogated by the selective depletion of NK cells via the intraperitoneal injection of an anti-asialo GM-1 antibody.

The results suggest that Mel-P15 inhibits tumor growth in vivo by promoting NK cell cytotoxicity. Mel-P15 may therefore be a potential immunotherapy candidate for the treatment of hepatocellular carcinoma.

Saturday, December 02, 2017

Bee Bread Shows Antioxidant Activity and Protective Effect

Antioxidant activity and protective effect of bee bread (honey and pollen) in aluminum-induced anemia, elevation of inflammatory makers and hepato-renal toxicity

J Food Sci Technol. 2017 Dec;54(13):4205-4212

Aluminum toxicity might be related to oxidative stress, and the antioxidant activity and protective effect of bee bread, which contains pollen, honey and bees' enzymes, on aluminum induced blood and hepato-renal toxicity was investigated in rats.

Chemical analysis and antioxidant capacity of bee bread were conducted. The animal experiment in rats included; group 1: received distilled water (10 ml/kg b.wt), group 2: received aluminum chloride (662.2 mg/kg b.wt), group 3: received aluminum chloride (662.2 mg/kg b.wt) and ethanolic extract of the bee bread (500 mg/kg b.wt), and group 4: received aluminum chloride (662.2 mg/kg b.wt) and ethanolic extract of the bee bread (750 mg/kg b.wt). Doses were given once daily via a gavage. C-reactive protein, transaminases, urea, creatinine, creatinine clearance, sodium and potassium and urine sodium and potassium were determined on day 28 of the experiment.

Bee bread contained protein, fat, fiber, ash, carbohydrate, phenol and flavonoids and it exhibited antioxidant activity. Aluminum caused a significant elevation of blood urea, transaminase, C-reactive protein and monocyte count and significantly decreased hemoglobin. These changes were significantly ameliorated by the use of bee bread.

Bee bread has an antioxidant property, and exhibited a protective effect on aluminum induced blood and hepato-renal toxicity and elevation of inflammatory markers C-reactive protein, leukocyte and monocyte counts.

Friday, December 01, 2017

Honey Has Significant Diuretic Activity Alone or in Combination with Propolis

Antioxidant and diuretic activity of co-administration of Capparis spinosa honey and propolis in comparison to furosemide

Asian Pac J Trop Med. 2017 Oct;10(10):974-980

OBJECTIVE:

To study the antioxidant properties of Capparis spinosa (C. spinosa) honey and propolis and the effect of combined honey and propolis administration on urine volume and electrolytes in rats.

METHODS:

C. spinosa honey [1000 mg/kg body weight (b.wt)], propolis (100 mg/kg b.wt), honey/propolis mixture (C. spinosa honey 1000 mg/kg b.wt/ propolis extract 100 mg/kg b.wt ), distilled water (1 mL/kg b.wt) and furosemide (10 mg/kg b.wt) were orally administered to five groups of rats for 21 d. Urine volume, blood and urine sodium, potassium and chloride were measured. The antioxidant activity of propolis and honey was assessed and their total phenols and flavonoids were determined.

RESULTS:

Propolis and C. spinosa honey contain polyphenols including flavonoids and propolis demonstrated higher antioxidant activities than honey. Honey significantly increased urine volume and urine electrolyte excretion. Propolis had no significant effect on urine volume, but co-administration of propolis and honey caused significant diuresis. No major changes were observed in plasma electrolytes with the use of honey, propolis or their combination.

CONCLUSIONS:

Honey and propolis have antioxidant activity and contain polyphenols including flavonoids that are more pronounced in propolis. Honey has a significant diuretic activity alone or in combination with propolis. This is the first study comparing the diuretic effect of co-administration of propolis and C. spinosa honey with furosemide.

Thursday, November 30, 2017

Beeswax Component May Help Treat Ulcerative Colitis

[Effects in rats of bee-wax alcohols (D-002) on ulcerative colitis induced by dextran sulfate and ethanol].

Rev Peru Med Exp Salud Publica. 2017 Apr-Jun;34(2):176-182

OBJECTIVES.:

To investigate the effects of D-002, a mixture of 6 high molecular weight primary aliphatic alcohols, obtained from beeswax (Apis mellifera), on severe inflammatory ulcerative colitis (UC) induced by Dextran sulfate (DSS) and ethanol in rats (Ratus ratus).

MATERIALS AND METHODS.:

Rats were randomly distributed in six groups: a zero control to which no damage was caused, and five to which the UC was induced: a negative control (vehicle), three treated with D-002 (25, 100 and 400 mg/kg) and a positive control with sulfasalazine (200 mg/kg) (reference substance). Clinical manifestations (body weight variation, diarrhea and rectal bleeding), macroscopic and histological damage score, and myeloperoxidase (MPO) activity were quantified.

RESULTS.:

The oral treatment with D-002 (25, 100 and 400 mg/ kg) significantly prevented the decrease in body weight. The dose of 400 mg/kg reduced the presence of diarrhea and rectal bleeding, although its comparison with the negative control only reached statistical significance on diarrhea. D-002 (25, 100 and 400 mg/kg) significantly reduced the score of macroscopic lesions (40.0; 43.3 and 47.2% inhibition, respectively), the histological damage score (31.5; 53.7 and 67.1% inhibition, respectively) and the activity of MPO (73.2; 83.6 and 85.0% inhibition, respectively), compared to the negative control group. Sulfasalazine significantly reduced all variables studied.

CONCLUSIONS.:

D-002 (25, 100 and 400 mg/kg) significantly protected the colonic mucosa in rats with severe inflammatory UC induced by DSS and ethanol.

Tuesday, November 28, 2017

Webinar November 29 on Apitherapy and Veterinary Medicine

CAA Webinar with French Veterinarian/Apitherapist Philippe Garcia

Date: November 29, 2017 Time: 2:30 pm (EST) Host: Canadian Apitherapy Association

GO TO: https://www.canadian-apitherapy-association.ca/webinars/caa-webinar-with-french-veterinarianapitherapist-philippe-garcia/ 

Our first webinar talking about the use of apitherapy in the realm of Veterinary Medicine.

Welcome and enjoy the conference of our French Veterinarian/Apitherapist Philippe Garcia.

The Webinar will be directly translated in English by Yann Loranger, Secretary/Treasurer of the Canadian Apitherapy Association.

Monday, November 27, 2017

German Apitherapy Congress, Expo and Workshops March 23-27, 2018

The XVI-th. German Apitherapy Congress, Expo and Workshops with international participation, Passau, IBB Hotel City Centre, March 23-27, 2018. For more details contact Dr Stefan Stangaciu to drstangaciu@gmail.com


Saturday, November 25, 2017

Bee Venom Peptide May Help Treat Liver Cancer

The anti-hepatocellular carcinoma activity of Mel-P15 is mediated by natural killer cells

Oncol Lett. 2017 Dec;14(6):6901-6906

Mel-P15 is a peptide derived from melittin, the main toxic component in the venom of the European honeybee Apis mellifera.

In the present study, the antitumor effects of Mel-P15 and the underlying molecular mechanisms of these effects in vivo were investigated. Mel-P15 directly stimulated natural killer (NK) cell cytotoxicity in vitro, which was increased to 55.45% at a 4 µg/ml dose of Mel-P15.

In the mouse liver cancer (H22) xenograft mice model, Mel-P15 suppressed tumor growth in vivo; the tumor inhibitory rate was 61.15% following treatment with 2 mg/kg Mel-P15. In addition, the immune response was activated following Mel-P15 treatment. Mel-P15 treatment increased the spleen and thymus indices, promoted splenocyte proliferation, stimulated NK cytotoxicity and upregulated the secretion of cytokines, including interleukin-2, interferon-γ and tumor necrosis factor-α.

In addition, the tumor inhibitory effect of Mel-P15 on BEL-7402-bearing nude mice was abrogated by the selective depletion of NK cells via the intraperitoneal injection of an anti-asialo GM-1 antibody.

The results suggest that Mel-P15 inhibits tumor growth in vivo by promoting NK cell cytotoxicity. Mel-P15 may therefore be a potential immunotherapy candidate for the treatment of hepatocellular carcinoma.

Thursday, November 23, 2017

Propolis, Honey Component Shows Anti-Inflammatory, Anti0cancer, and Anti-Viral Activities

Chrysin: Sources, beneficial pharmacological activities, and molecular mechanism of action

Phytochemistry. 2017 Nov 18;145:187-196

In recent years, public and scientific interest in plant flavonoids has tremendously increased because of their postulated health benefits.

This review was mainly focuses on the flavone chrysin (5,7-dihydroxyflavone), which occurs naturally in many plants, honey, and propolis. A number of in vitro and in vivo studies have revealed the therapeutic effects of chrysin against various diseases.

In general, chrysin exhibits many biological activities and pharmacological effects, including antioxidant, anti-inflammatory, anticancer, and antiviral activities. Moreover, many studies have reported on the bioavailability of chrysin. Because of its compromised bioavailability and enhanced protein stability, chrysin solid lipid nanoparticle (SLN) synthesis avoids proteolytic degradation and sustained release of drug delivery.

To clarify the mechanism of action of chrysin, researchers have investigated the structural binding relationship of chrysin through the docking computation method.

Wednesday, November 22, 2017

Ukrainian Honey-Propolis Gum Prevents Periodontal Disease


Made in Ukraine: periodontal disease treatment chewing gum 

Ukraine Good News, 11/21/2017

Marta Tsap, an Ivano-Frankivsk National Medical University student, presented a chewing gum based on bactericidal and antiseptic properties of honey to prevent oral cavity diseases. The product is a great way to treat and prevent periodontal disease.

The chewing gum is based on caramelized honey, its effect was tested by the university dentistry faculty experts. The periodontium state of 6 out of 9 volunteers using the chewing gum for a month has improved.

In addition to honey, the gum contains wax, propolis and other beekeeping products.

As Marta says, the chewing gum is ready for serial production launch. The honey gum production start requires 209,000 UAH. The project will pay off in 2 years.

Tuesday, November 21, 2017

Propolis May Help Protect Against Radiation Damage

Radio-Modulatory Potential ofCaffeic Acid Phenethyl Ester: A Therapeutic Perspective

Anticancer Agents Med Chem. 2017 Nov 13

Use of natural agents is an upcoming area of research in cancer biology. Caffeic acid phenethyl ester has received great attention because of its therapeutic potential in various conditions including cancer. It is an active/abundant component of propolis. Propolis is a honey bee hive product produced by bees using their enzyme-rich digestive secretions on resinous mix, bee wax and pollen from plants. It is used to protect the beehive against bacteria and other infections.Although a lot of work has been done on chemotherapeutic aspects of CAPE, its role as a radiomodulator is yet to be delineated. It can act both as radioprotector and radiosensitizer. Depending on the tissue type it can modulate the radiation response by following different mechanisms.

This review will focus on the differential radiomodulatory effects of Caffeic Acid Phenethyl Ester in normal and cancer cells.Besides chemistry and bioavailability,it's potential as a therapeutic agent against radiation induced damage will also be discussed.

Monday, November 20, 2017

Propolis: This Bee Product is a Powerful Natural Immune Booster

By: Jordyn Cormier, November 19, 2017

Cold and flu season is in full swing, which means it’s time to start bringing on immune boosters again. Some of us will chug freshly squeezed orange juice. Others will slam shots of elderberry kombucha. A few will start force-feeding themselves and their family pungent raw garlic, all in a martyrish effort to avoid getting sick. But there is probably something even more powerful missing from your natural immune defense arsenal…propolis.

Propolis is one of the most undervalued natural immune boosters out there. Personally, I use my propolis spray daily. After years of getting sick every cold/flu season, a friend sent me some propolis to try. Ever since then, even the most inevitable colds seem to repel off of me. It’s pretty amazing.

If you are unfamiliar with propolis, it is a bee product, much like honey is—but that’s where the similarities end. Bees use propolis to keep their hives free of invaders and disease. It lines the hive walls and acts essentially as the immune system of the hive. And guess what—it can do the same for your body...

Sunday, November 19, 2017

Turkish Honeys Beat Manuka Antibacterial Properties

Turkish honey beats world famous Manuka honey, study finds

DAILY SABAH

The flower honey from Turkey's southeastern province of Hakkari has much higher antimicrobial capabilities compared to the world famous Manuka honey of Australia and New Zealand, a new study has found.

Sevgi Kolaylı, a chemistry professor at the Karadeniz Technical University in Trabzon, says her recent study has found that several kinds of honey gathered from different parts of Turkey showed much higher antimicrobial activity compared to Manuka honey.

Kolaylı's study found that antimicrobial activities, which makes honey act against bacteria like antibiotics, are significantly higher in flower honey from Hakkari province compared to Manuka.

Several kinds of Turkish chestnut and oak honey also showed higher antibacterial properties, Kolaylı said.

The professor also said that Turkey ranks only behind China and Argentina as the world's top honey producing country.

"Antioxidant properties are richer in dark colored honey, whereas antimicrobial activities are higher in lighter colored honey," the professor explained, and added that Turkey is home to rich honey from both spectrums.

Saturday, November 18, 2017

Ethanolic Extract of Polish Propolis Boosts Oral Hygiene

The Influence of Toothpaste Containing Australian Melaleuca alternifolia Oil and Ethanolic Extract of Polish Propolis on Oral Hygiene and Microbiome in Patients Requiring Conservative Procedures

Molecules. 2017 Nov 13;22(11). pii: E1957

The study was based on the use of a toothpaste with antiphlogistic activity, containing Australian Melaleuca alternifolia oil (tea tree oil-TTO) and ethanolic extract of Polish propolis (EEP). Fifty-one patients with varying conditions of the gingiva were divided into two groups.

The study group received the toothpaste with TTO and EEP, while the control group received the same toothpaste but without TTO and EEP. Approximal plaque index (API), simplified oral hygiene index (OHI-s) and modified sulcus bleeding index (mSBI) were assessed in three subsequent stages. During each examination, swabs were employed for microbiological inoculation. During the period of use of toothpastes with TTO and EEP, a significant reduction of the API was observed, as assessed upon the control visit after 7 days and after 28 days, compared to baseline. A statistically significant reduction of mSBI was observed after 7 and 28 days of using the toothpaste with TTO and EEP, as compared to the value upon the initial visit. Statistically significant differences in the OHI-s value were observed in the study group, which was using the active toothpaste. The use of a toothpaste containing TTO and EEP helps to maintain microbiome balance.

The observed stabilisation of bacterial microflora confirms the beneficial activity of toothpaste containing EEP and TTO compared to the control group, where the lack of these substances contributed to the emergence of qualitative and quantitative changes in oral microbiome.

Honey: A Therapeutic Agent for Disorders of the Skin

Cent Asian J Glob Health. 5(1):241

Problems with conventional treatments for a range of dermatological disorders have led scientists to search for new compounds of therapeutic value. Efforts have included the evaluation of natural products such as honey. Manuka honey, for example, has been scientifically recognised for its anti-microbial and wound healing properties and is now used clinically as a topical treatment for wound infections. In this review, scientific evidence for the effectiveness of honey in the treatment of wounds and other skin conditions is evaluated. A plethora of in vitro studies have revealed that honeys from all over the world have potent antimicrobial activity against skin relevant microbes. Moreover, a number of in vitro studies suggest that honey is able to modulate the skin immune system.

Clinical research has shown honey to be efficacious in promoting the healing of partial thickness burn wounds while its effectiveness in the treatment of non-burn acute wounds and chronic wounds is conflicted. Published research investigating the efficacy of honey in the treatment of other types of skin disorders is limited. Nevertheless, positive effects have been reported, for example, kanuka honey from New Zealand was shown to have therapeutic value in the treatment of rosacea. Anti-carcinogenic effects of honey have also been observed in vitro and in a murine model of melanoma.

It can be concluded that honey is a biologically active and clinically interesting substance but more research is necessary for a comprehensive understanding of its medicinal value in dermatology.

Friday, November 17, 2017

Powder Containing Extract of Green and Red Propolis a Possible Antimicrobial Agent

Evaluation of the antimicrobial activity and cytotoxic effect of hydroxyapatite containing Brazilian propolis

Biomed Mater. 2017 Nov 14

The aim of this work was to produce hydroxyapatite powder (HA) containing dry extract of green and red propolis, and to evaluate possible bactericidal activity of the materials in a short period of time through a fast release system.

The ethanolic extracts of green and red propolis (EEP) were incorporated into the material by spray drying. After release tests, powders containing dry EEP were characterized regarding the content of total phenolics and flavonoids. Materials characterization was made by scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR). The antimicrobial activity was evaluated by plate colony counting, minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) against Staphylococcus aureus (S. aureus). The cytotoxicity of the materials was determined by the neutral red incorporation method. Materials showed apparently spherical morphology, indicating a decrease in the agglomeration degree with the propolis addition.

HA and propolis characteristic functional groups were observed in FTIR. Materials had higher release of phenolics and lesser amounts of flavonoids when compared to the EEP, with the higher amounts of flavonoids observed for HA with red propolis. The bactericidal effect for all materials was observed within the interval of 0.5 to 1 hour. All materials showed lesser inhibitory activity (MIC) and higher bactericidal activity (MBC) when compared to the EEP, with the best results attributed to HA with red propolis. The values of IC50 (concentration needed to inhibit 50% of the cell growth) obtained from the cytotoxicity assay for HA with green and red propolis lied between MIC and MCB.

Considering these results, it is suggested that HA with propolis may be used as a possible antimicrobial agent, inhibiting the growth of S. aureus, despite further in vivo biocompatibility should be investigated before using this material as a medical device with bactericidal potential.

Thursday, November 16, 2017

Ginger and Propolis Exert Neuroprotective Effects

Ginger and Propolis Exert Neuroprotective Effects against Monosodium Glutamate-Induced Neurotoxicity in Rats

Molecules. 2017 Nov 8;22(11). pii: E1928

Central nervous system cytotoxicity is linked to neurodegenerative disorders. The objective of the study was to investigate whether monosodium glutamate (MSG) neurotoxicity can be reversed by natural products, such as ginger or propolis, in male rats.

Four different groups of Wistar rats were utilized in the study. Group A served as a normal control, whereas group B was orally administered with MSG (100 mg/kg body weight, via oral gavage). Two additional groups, C and D, were given MSG as group B along with oral dose (500 mg/kg body weight) of either ginger or propolis (600 mg/kg body weight) once a day for two months. At the end, the rats were sacrificed, and the brain tissue was excised and levels of neurotransmitters, ß-amyloid, and DNA oxidative marker 8-OHdG were estimated in the brain homogenates. Further, formalin-fixed and paraffin-embedded brain sections were used for histopathological evaluation.

The results showed that MSG increased lipid peroxidation, nitric oxide, neurotransmitters, and 8-OHdG as well as registered an accumulation of ß-amyloid peptides compared to normal control rats. Moreover, significant depletions of glutathione, superoxide dismutase, and catalase as well as histopathological alterations in the brain tissue of MSG-treated rats were noticed in comparison with the normal control. In contrast, treatment with ginger greatly attenuated the neurotoxic effects of MSG through suppression of 8-OHdG and β-amyloid accumulation as well as alteration of neurotransmitter levels.

Further improvements were also noticed based on histological alterations and reduction of neurodegeneration in the brain tissue. A modest inhibition of the neurodegenerative markers was observed by propolis.

The study clearly indicates a neuroprotective effect of ginger and propolis against MSG-induced neurodegenerative disorders and these beneficial effects could be attributed to the polyphenolic compounds present in these natural products.

Wednesday, November 15, 2017

Antimicrobial Effect of Ginger, Garlic, Honey, and Lemon Extracts on Streptococcus mutans

J Contemp Dent Pract. 2017 Nov 1;18(11):1004-1008.

The aim of this study was to evaluate the effect of lemon, ginger, garlic, and honey extracts on Streptococcus mutans.

MATERIALS AND METHODS:

Commercially obtained honey, ginger, garlic, and lemon were included in the study to evaluate its efficacy in isolation and in combination against S. mutans. The efficacies of extracts were tested using well diffusion method, and its effect was evaluated by measuring the zone of inhibition around the well. Antimicrobial activity of the extracts was carried out individually and compared considering triplicates of all the extracts.

RESULTS:

When individual comparison of the extracts was made, garlic showed greatest antimicrobial activity with a mean zone of inhibition (34.9 ± 0.58 mm) and honey showed least antimicrobial activity (0.5 ± 0.6 mm). When combinations of extracts were tested against S. mutans, lemon and garlic combination showed the greatest zone of inhibition (27.6 ± 0.43 mm) compared with other combinations, and ginger + lemon combinations showed the least zone of inhibition (12.6 ± 0.43 mm).

CONCLUSION:

This study concluded that garlic showed a greatest antimicrobial effect against S. mutans when compared with other preparations individually and garlic and lemon showed greatest zone of inhibition in combination than other preparations.

CLINICAL SIGNIFICANCE:

Antibiotics and other chemical agents are mainly used to treat the common dental infections. However, due to the excessive use, it can result in antibiotic resistance. Hence, herbal medicines with medicinal values should be replaced with conventional methods.

Tuesday, November 14, 2017

Honey Polyphenols May Help Treat Cardiovascular Diseases, Diabetes, Cancer, and Neurodegenerative Disorders

Beneficial roles of honey polyphenols against some human degenerative diseases: A review

Pharmacol Rep. 2017 Jul 4;69(6):1194-1205

Honey contains many active constituents and antioxidants such as polyphenols. Polyphenols are phytochemicals, a generic term for the several thousand plant-based molecules with antioxidant properties.

Many in vitro studies in human cell cultures as well as many animal studies confirm the protective effect of polyphenols on a number of diseases such as cardiovascular diseases (CVD), diabetes, cancer, neurodegenerative diseases, pulmonary diseases, liver diseases and so on. Nevertheless, it is challenging to identify the specific biological mechanism underlying individual polyphenols and to determine how polyphenols impact human health. To date, several studies have attempted to elucidate the molecular pathway for specific polyphenols acting against particular diseases.

In this review, we report on the various polyphenols present in different types of honey according to their classification, source, and specific functions and discuss several of the honey polyphenols with the most therapeutic potential to exert an effect on the various pathologies of some major diseases including CVD, diabetes, cancer, and neurodegenerative diseases.

Monday, November 13, 2017

Royal Jelly as Skin Moisturizing Agent

10-Hydroxy-2-Decenoic Acid in Royal Jelly Extract Induced Both Filaggrin and Amino Acid in a Cultured Human Three-Dimensional Epidermis Model

Cosmetics 2017, 4(4), 48

Royal jelly (RJ) is a natural product which the honeybee secretes as a special diet for a queen bee. It is one of the natural products in which various functionalities, such as antibacterial effects, immunomodulating properties, and estrogen-like action, were reported.

We investigated the effect of the RJ extract on the moisturizing effect by topical application in humans. The stratum corneum moisture was increased significantly after four weeks by using the RJ extract lotion compared to placebo lotion. RJ extract contained a characteristic ingredient, 10-hydroxy-2-decenoic acid (10H2DA) and 10-hydroxydecanoic acid (10HDAA), etc. However, the mechanism of stratum corneum moisture and its contributing ingredient have not yet been elucidated.

We have investigated the effects of 10H2DA and 10HDAA on the free amino acids content in the stratum corneum using a cultured human three-dimensional epidermis model. Additionally, the effect of 10H2DA and 10HDAA on the amounts of filaggrin (FLG) and aquaporin 3 (AQP3) were investigated at the mRNA level and by immunohistochemistry using a cultured human epidermis model. It was determined that 10H2DA increases the free amino acids in the stratum corneum of the cultured human epidermis model, and that it increased FLG on both the mRNA and protein levels. On the other hand, these actions are not observed by treatment of 10HDAA. The mRNA and protein level of AQP3 did not increase with 10H2DA or 10HDAA use.

It was thought that the increase in the amount of FLG and the increase in the free amino acids of the epidermis and the stratum corneum, respectively, by 10H2DA were participating in the moisturizing function of the stratum corneum by the continuous use of RJ extract lotion.

Sunday, November 12, 2017

New Product Uses Propolis, Bee Venom, Wax Moth Extract to Treat Joint and Tissue Pain

SustaFix LLC Created a Honey-Based Product for Treating Joint and Tissue Pain

November 10, 2017 --(PR.com)-- A novel honey-based product for treating joint and tisssue pain has been created and manufactured in Atlanta, Georgia. SustaFix gel contains propolis extract, bee venom, bee extract, beeswax, cedar sap, olive oil, horse chestnut extract and wax moth extract. Additional ingredients embaded in product's formula include vitamins C, B1, and B5, which play role in strengthening the vein muscle walls and tissue regeneration. Other ingredients include substances that possess vasodilatory and painkilling properties. SustaFix's action is pointed at relieving the inflammation, eliminating pain and swelling of joints, and repressing the symptoms of arthritis and arthrosis.

The use of honey for medical purposes is known for decades as alternative or complementary medicine. Today it is gaining popularity not only in the United States, but Europe and Asia as well. According to a research, made by National Center for Complementary and Alternative Medicine in 2007 (https://nccih.nih.gov/sites/nccam.nih.gov/files/camuse.pdf), almost 40 percent of adults in America use some form of alternative medicine. It is known that honey is widely used in treating a variety of medical conditions, including arthritis, joint a, promotes burn and wound healing, and helps in suppressing cough.

SustaFix beeswax gel smooth consistency makes it easily applicable on the affected areas. A small amount of the gel should be spread on the area of concern and then - gently massaged until its full absorption. Tube contains 100 ml substance, that should be applied once or twice a day depending on the severity of the condition.

Saturday, November 11, 2017

Propolis Prevents Biodegradation of Natural Rubber

Propolis as an antidegradant and biocidal agent for natural rubber

Journal of Applied Polymer Science

First published: 7 November 2017

The numerous applications of polymers in many areas of our lives make it necessary to protect them from aging. Increases in the safety and time of polymer material exploitation demands the application of antidegradants with broad scopes of action.

In this study, crude propolis, originating from two geographical regions of Poland, was used to protect peroxide-cured natural-rubber vulcanizates filled with silica or carbon black from degradation by oxygen, ozone, and microorganisms. Thermogravimetry analysis confirmed the stability of propolis under the curing conditions. From vulcametric torque measurements and determinations of the mechanical properties, we determined that the incorporation of propolis did not adversely affect the performance of the natural-rubber vulcanizates.

The addition of propolis to the rubber mix made the vulcanizates resistant to thermooxidative and ozone aging and protected them from biodegradation in soil and the action of microorganisms.

Friday, November 10, 2017

Bee Venom Acupuncture Helps Treat Lower Back Pain

Efficacy of Bee Venom Acupuncture for Chronic Low Back Pain: A Randomized, Double-Blinded, Sham-Controlled Trial

Toxins 2017, 9(11), 361

Bee venom acupuncture (BVA) is an effective treatment for chronic low back pain (CLBP) through the pharmacological effects of bee venom and the simultaneous stimulation of acupoints. However, evidence of its efficacy and safety in humans remains unclear.

Using a double-blind, randomized study, 54 patients with non-specific CLBP were assigned to the BVA and sham groups. All participants underwent six sessions of real or sham BVA for 3 weeks, in addition to administration of 180 mg of loxonin per day. The primary outcome, that is, “bothersomeness” derived from back pain, was assessed using the visual analog scale. Secondary outcomes included pain intensity, dysfunction related to back pain (Oswestry Disability Index), quality of life (EuroQol 5-Dimension), and depressive mood (Beck’s depression inventory). Outcomes were evaluated every week during the treatment period and followed up at weeks 4, 8, and 12.

After 3 weeks of the treatment, significant improvements were observed in the bothersomeness, pain intensity, and functional status in the BVA group compared with the sham group. Although minimal adverse events were observed in both groups, subsequent recovery was achieved without treatment.

Consequently, our results suggest that it can be used along with conventional pharmacological therapies for the treatment of CLBP.

Thursday, November 09, 2017

Charles Mraz Apitherapy Course and Conference (CMACC)

Theory In Practice, A Hands-On Approach

November 10-12 2017

The Redondo Beach Hotel

400 N. Harbor Drive

Redondo Beach, CA 90277

310-376-0746

Bee Venom Component May Help Treat Hepatitis B

Medical Express, 11/7/2017

"We now have a drug that can knock down hepatitis B surface antigen and determine whether or not we can actually cure people with that," Dr. Lanford said.

The drug is delivered by subcutaneous (under the skin) injection. Scientists designed a molecule that delivers the medicine directly to the liver where it binds to a receptor. Then, another molecule that's derived from bee venom, helps break through membranes in the liver cells to deliver the medicine directly into the cytoplasm of the cells where it takes effect. The siRNA interferes with the expression of the HBV messenger RNA that produces the surface antigen...

Wednesday, November 08, 2017

Indian Propolis as a Potential Nutraceutical Candidate

Marker-based standardization and investigation of nutraceutical potential of Indian propolis

J Integr Med. 2017 Nov;15(6):483-494

OBJECTIVE:

Propolis, a resinous material collected by honey bees from various plants, has been explored globally for its medicinal and nutritional properties. However, research over Indian propolis is at infancy. This study was designed to investigate nutraceutical potential of Indian propolis.

METHODS:

In the present study, propolis extract was standardized with respect to markers caffeic acid phenethyl ester, caffeic acid, galangin, luteolin, curcumin, apigenin, pinocembrin and quercetin by new high-performance thin-layer chromatographic (HPTLC) methods. The physico-chemical analysis, residues analysis and in vitro antioxidant activity analysis were performed. Nutraceutical value was examined in terms of fats, fibers, minerals, proteins, polysaccharides, total carbohydrates, and energy value.

RESULTS:

The developed HPTLC methods were found to be simple, reliable accurate, and the validation parameters were within the limits of the International Council for Harmonization of Technical Requirements for Pharmaceuticals for Human Use guidelines. Macerated ethanolic extract of propolis (MEEP) was found to have polyphenolic content of (20.99 ± 0.24) mg/g and flavonoids content of (8.39 ± 0.04) mg/g. MEEP was found to comprise of (283.33 ± 51.31) g/kg fats, (30.07 ± 7.30) g/kg fibers, (102.56 ± 2.84) g/kg proteins and (389.36 ± 57.50) g/kg carbohydrate with a calorie value of (38 409.33 ± 6 169.80) kJ/kg. It was found that Indian propolis exhibited high nutraceutical value and showed absence of pesticides and heavy metals. The MEEP showed in vitro antioxidant activity with inhibitory concentration of (12.24 ± 4.64) μg/mL.

CONCLUSION:

The present work explores Indian propolis as a potential nutritious candidate. The proposed analytical methods can be applied in future screening of the quality of Indian propolis.

Tuesday, November 07, 2017

Honey May Help Eradicate Methicillin Sesistant Staphylococcus Aureus (MRSA)

Randomised controlled trial of honey versus mupirocin to decolonise patients with nasal colonisation of methicillin resistant Staphylococcus aureus and the lessons learned

J Hosp Infect. 2017 Oct 26. pii: S0195-6701(17)30582-0

AIM:

To describe the learning experience from a randomised controlled trial (RCT) comparing the efficacy of medical-grade honey (MGH) with mupirocin 2% for the eradication of nasal methicillin-resistant Staphylococcus aureus (MRSA).

METHODS:

Patients colonised in the nose with MRSA and age ≥18 years were recruited. Participants received either one or two courses of MGH or mupirocin 2%, three times per day for five consecutive days.

RESULTS:

The proportion of patients who were decolonised after one or two courses of treatment was not significantly different between MGH (18/42; 42.8%; 95% CI: 27.7% - 59.0%), and mupirocin 2% (25/44; 56.8%; 95% CI: 41.0% - 71.7%). Non-nasal MRSA colonisation was significantly associated with persistent nasal colonisation, (p = 0.003, OR, 5.186, 95% CI: 1.736 - 15.489). The rate of new acquisition of mupirocin resistance was 9.75%.

CONCLUSIONS:

Although not significant, a decolonisation rate of 42.8% for MGH was impressive. In the absence of other effective agents, MGH has a potentially clinically important role. Our findings suggest this strategy, which has the potential to combat antimicrobial resistance, should be assessed in similar but larger studies. Studies of natural agents where there is no commercial patent and which are, therefore, unlikely to be funded by industry, need to be adequately funded by national and or international agencies so that well designed multi-centre RCTs can be carried out which may provide alternatives to antibiotics where resistance is a continuing challenge. The lessons learned may help guide future studies in determining realistic recruitment potential.

Monday, November 06, 2017

Malaysian Stingless Bee Honey High in Anti-Oxidants

Malaysian stingless bee and Tualang honeys: A comparative characterization of total antioxidant capacity and phenolic profile using liquid chromatography-mass spectrometry

LWT - Food Science and Technology
Volume 89, March 2018, Pages 1-9

• Malaysian Stingless bee honey has higher vitamin C, protein, polyphenols content than Tualang honey.
• LC-MS identified several phenolic compounds in stingless bee honey.
• Stingless bee honey had the highest anti-oxidant performance.
• Polyphenol content of stingless bee honey was associated with antioxidant activities.

This study aims to examine and compare the phenolic profile and antioxidant properties of two kinds of honey: Stingless bee honey (Kelulut honey) and Tualang honeys. Using liquid chromatography mass spectrometry, a total of eighteen phenolic acids and flavonoids have been identified in Kelulut honey samples. The phenolic content and total antioxidant capacity (three assays: DPPH, ABTS, and ORAC) for Kelulut and Tualang honeys were evaluated and statistically estimated. There was a significant (p < 0.05) phenolic content (228.09 ± 7.9–235.28 ± 0.6 mg gallic acid equivalent per kg) and flavonoid content (97.88 ± 10.1–101.5 ± 11.4 mg catechin equivalent per kg) in Kelulut honey samples. The Kelulut honey samples have demonstrated a significantly stronger antioxidant capacity than Tualang honey samples. The correlations between antioxidant results and polyphenols content were found to be statistically significant (P < 0.05, P < 0.01). This research is the first to report data on phenolic profile and total antioxidant capacity of Kelulut honey. Our data suggest that Kelulut honey has prominent medical properties and could be exploited as a natural nutraceutical to treat free radical associated diseases.

Sunday, November 05, 2017

Review of Medicinal Uses of Honey

Towards a better understanding of the therapeutic applications and corresponding mechanisms of action of honey

Environ Sci Pollut Res Int. 2017 Nov 3

Honey is a bee-derived supersaturated solution composed of complex contents mainly glucose, fructose, amino acids, vitamins, and minerals. Composition of honey may vary due to the difference in nectar, season, geography, and storage condition. Honey has been used since times immemorial in folk medicine and has recently been rediscovered as an excellent therapeutic agent.

In the past, honey was used for a variety of ailments without knowing the scientific background and active ingredients of honey. Today, honey has been scientifically proven for its antioxidant, regulation of glycemic response, antitumor, antimicrobial, anti-inflammatory, and cardiovascular potentiating agent. It can be used as a wound dressing and healing substance. Honey is different in color, flavor, sensory perception, and medical response. Apart from highlighting the nutritional facts of honey, we collected the finding of the published literature to know the mechanism of action of honey in different diseases.

This review covers the composition, physiochemical characteristics, and some medical uses.

Friday, November 03, 2017

Bee Venom Acupuncture May Help Treat Chronic Pain


Suppressive Effects of Bee Venom Acupuncture on Paclitaxel-Induced Neuropathic Pain in Rats

Toxins 2017, 9(11), 351

Paclitaxel, a chemotherapy drug for solid tumors, induces peripheral painful neuropathy. Bee venom acupuncture (BVA) has been reported to have potent analgesic effects, which are known to be mediated by activation of spinal α-adrenergic receptor.

Here, we investigated the effect of BVA on mechanical hyperalgesia and spinal neuronal hyperexcitation induced by paclitaxel. The role of spinal α-adrenergic receptor subtypes in the analgesic effect of BVA was also observed. Administration of paclitaxel (total 8 mg/kg, intraperitoneal) on four alternate days (days 0, 2, 4, and 6) induced significant mechanical hyperalgesic signs, measured using a von Frey filament. BVA (1 mg/kg, ST36) relieved this mechanical hyperalgesia for at least two hours, and suppressed the hyperexcitation in spinal wide dynamic range neurons evoked by press or pinch stimulation.

Both melittin (0.5 mg/kg, ST36) and phospholipase A2 (0.12 mg/kg, ST36) were shown to play an important part in this analgesic effect of the BVA, as they significantly attenuated the pain. Intrathecal pretreatment with the α2-adrenergic receptor antagonist (idazoxan, 50 µg), but not α1-adrenergic receptor antagonist (prazosin, 30 µg), blocked the analgesic effect of BVA.

These results suggest that BVA has potent suppressive effects against paclitaxel-induced neuropathic pain, which were mediated by spinal α2-adrenergic receptor.

Thursday, November 02, 2017

Propolis as a Remedy for Toe Nail Fungus

5. Propolis solution

The more you apply the alcohol solution of propolis on the affected areas, that is, of course, better. You will be pleasantly surprised how fast will be the effect of the propolis. But note that even with the disappearance of the external manifestations of the disease, treatment should continue for some time. This completely eliminates the possibility of re-emergence of the fungus.

Wednesday, November 01, 2017

Vietnamese Propolis May Help Treat Cancer


A surprise discovery: Vietnam’s propolis can help treat cancer

VIETNAM.NET

Biologically, propolis is a mixture of resins and secretions from the honey bee’s salivary gland, which is flexible and glutinous at high temperatures but hard and fragile at low temperatures.

Studies have found more than 149 compounds and 22 different types of minerals in propolis. These compounds have many biological activities: antioxidant, antimicrobial, antiviral, anti-fungal, anti-inflammatory and anti-cancer.

Most of the products made of propolis take full advantage of its antibacterial characteristics. Bees use propolis to stabilize the structure of the nest, reduce vibration, mend tears and cracks of the nest. This strengthens the defense of the nest by blocking the entrance, prevents parasites and invasive bacteria, restricts the development of bacteria, fungi, and prevents any possibility of spreading harmful disease.

The best known propolis products available in the market are from South American countries, including Green Propolis which has very strong antibacterial activity, used to prevent flu.

Vietnam’s propolis has weaker antioxidant and antimicrobial activity. However, Vietnam’s propolis has very strong anti-cancer activity, especially pancreatic cancer.
Mai and her co-workers found that the propolis of Apis mellifera, which is raised in Vietnam, has flavonoid and polyphenol compounds much lower than the Brazilian honey bee, by 3-10 times.

Therefore, Vietnam’s propolis has weaker antioxidant and antimicrobial activity. However, Vietnam’s propolis has very strong anti-cancer activity, especially pancreatic cancer...

Tuesday, October 31, 2017

Honey Producers Stick Together in Manuka Trademark Fight

HELEN KEMPTON, Mercury, October 31, 2017

A NATIONAL campaign spearheaded by a honey producer in Tasmania’s North-West is gaining wings as beekeepers band together to stop New Zealand producers trademarking the word Manuka.

Manuka honey, derived from the tea tree (leptospermum) native to Tasmania, can retail for as much as $120 a jar and is deemed a health product because of its antibacterial properties.

There are five commercial Manuka honey producers in Tasmania and a number of smaller operations that provide them with the liquid gold.

In response to the trademark application in NZ, the Australian honey industry has collectively formed the Australian Manuka Honey Association to formally oppose any attempts to monopolise international naming or market rights...

Monday, October 30, 2017

Nutritional and Medicinal Properties of Honey

Honey - ancient, golden wonder

Sunday, October 29, 2017

HONEY is the world's oldest natural unprocessed sweetener. It's a power bank of health benefits and a key to health and wealth. If you're not taking full advantage of the nutritional and medicinal properties of honey, it's time to begin because honey is a remarkable healing agent for all sorts of ailments.

A quick search on its health benefits shows it contains flavonoids, antioxidants which help reduce the risk of some cancers and heart disease as well as reduce ulcers and other gastrointestinal disorders. Honey is known for its anti-bacterial, anti-fungal properties for healing since ancient times. The Greeks, Romans, and Egyptians documented the healing properties of honey as early as Aristotle's mention of it in 384 BC. Even King Solomon said in the Bible: "My son, eat thou honey, for it is good."

Even doctors apply honey on wounds to speed up healing and diabetics use honey as their sugar replacement...

Sunday, October 29, 2017

Manuka Honey as Cancer-Fighting Agent

UAEU research into curative properties of Manuka honey reaches new breakthrough

The National

A UAE University team has found that Manuka honey effectively inhibits the growth of a variety of cancerous cells. Rich-Joseph Facun / The National
The beneficial health effects of high-quality honey have long been documented by researchers.

As Philip McCabe, president of the world beekeeping federation likes to say, “Honey was a medicine before medicine was even invented.”

Scholars at the United Arab Emirates University recently reached a new breakthrough in their years-long study of Manuka honey as a cancer-fighting agent.

The research team, led by Dr Basel Al-Ramadi, professor of cancer immunology at UAEU, discovered that Manuka honey — when injected as part of a medical concoction — helped combat the growth of several types of cancer cells....

Saturday, October 28, 2017

Bee Venom May Help Treat Internal Parasites

Low virulence potential and in vivo transformation ability in the honey bee venom treated Clinostomum complanatum

Exp Parasitol. 2017 Oct 22. pii: S0014-4894(17)30456-3

The helminth parasites possess great capabilities to adapt themselves within their hosts and also develop strategies to render the commonly used anthelmintics ineffective leading to the development of resistance against these drugs. Besides using anthelmintics the natural products have also been tested for their anti-parasitic effects.

Therapeutic efficacy of honey bee venom (HBV) has been tested in various ailments including some protozoal infections but very little is known about its anthelmintic properties.

To investigate the anthelmintic effect of HBV the excysted progenetic metacercariae of Clinostomum complanatum, a heamophagic, digenetic trematode with zoonotic potential, infecting a wide variety of hosts, were obtained from Trichogaster fasciatus, a forage fish, which serves as the intermediate host. The metacercarial worms were in vitro incubated in RPMI-1640 medium containing HBV along with the controls which were devoid of HBV for the analysis of worm motility, enzyme activity, polypeptide profile and surface topographical changes. The motility of the worms was significantly reduced in a time dependent manner with an increase in the concentration of HBV.

Following incubation of worms the release of cysteine proteases was inhibited in the presence of HBV as revealed by gelatine substrate gel zymography. As well as the polypeptide profile was also significantly influenced, particularly intensity/expression of Mr 19.4 kDa, 24 kDa and 34 kDa was significantly reduced upon HBV treatment. The HBV treatment also inhibited antioxidant enzyme, superoxide dismutase (SOD) and Glutathione-S-transferase (GST) significantly (p < 0.05) in the worms.

The scanning electron microscopy of the HBV treated worms revealed tegumental disruptions and erosion of papillae as well as spines showing vacuolation in the tegument. The HBV treated worms also showed a marked decline in the transformation rate when introduced into an experimental host which further reflect the anthelmintic potential of HBV.

Friday, October 27, 2017

Bee Pollen, Propolis Boost Immune Response

Blood Hematological and Biochemical Constituents, Antioxidant Enzymes, Immunity and Lymphoid Organs of Broiler Chicks Supplemented with Propolis, Bee Pollen and Mannan Oligosaccharides Continuously or Intermittently

Poult Sci. 2017 Oct 10

This study investigate the effect of bee pollen (BP) and/or propolis (Pro) as an alternative to Mannan oligosaccharides (Bio-MOS, a hydrolyzed yeast with natural and artificial flavors Alltech Inc) when given continuously or intermittently on antioxidant enzymes, immunity, weight and morphology of lymphoid organs of broilers.

Thus, 324 unsexed one-day-old Arbor Acres broilers were randomly distributed into nine treatment groups, each replicated 6 times of 6 birds per replicate. The chicks were kept in wire cages and fed the same basal diet and were submitted to the following treatments: control without supplementation (control) or supplemented with BP at 300 mg, Pro at 300 mg, BP+Pro at 300 mg each and Bio-MOS at 0.5 g/kg diet.

Each supplemented group was subdivided into two subgroups in which the additives were supplied continuously or intermittently. In the continuously supplemented groups, supplementations were given from one till 36 days of age, and in the intermittently supplemented groups, the administration was only three days before, on the day of and day after vaccination. The BP and Pro supplied continuously or intermittently was equally potent for improving immunity, antioxidant enzymes similar to Bio-MOS. All supplements supplied either continuously or intermittently resulted a significantly higher thymus (P < .04) and bursa weights (P < .001) than the control group.

Combining BP with Pro resulted in a further increase in thymus weights and small follicle diameter compared to the control group. In addition, thymus percentage in the group received BP+Pro showed a further increase compared to the control and Pro supplemented intermittently. Bio-MOS, when supplied continuously or intermittently, resulted in the greatest response in splenic lymphoblasts.

Supplementation with either BP or Pro intermittently, is adequate to promote health and immune response of broiler chicks, with 40% saving of supplementation costs.

Thursday, October 26, 2017

Ultrasound Treatment is Recommended Over Thermal Processing of Honey

Effects of ultrasound and high pressure on physicochemical properties and HMF formation in Turkish honey types

Journal of Food Engineering
Volume 219, February 2018, Pages 129-136

In industrial production, thermal processing of honey at 50 °C commonly induces liquefaction, i.e. it reduces the crystal count and viscosity and delays any subsequent crystallization. Unfortunately, thermal treatment can generate toxic 5-hydroxymethylfurfural (HMF), thereby resulting in quality reduction.

Considering this, the present work aims at evaluating the influence of (two) processing technologies as alternatives to thermal processing of honey, namely high hydrostatic pressure (HHP; P = 220–330 MPa, T = 50/60 °C, t = 23/106 min), and ultrasound processing (US; at 24 kHz). The quality parameters evaluated for honey included liquefaction time, HMF content, diastase number, colour and viscosity. The best process conditions for maximising liquefaction were found to be P = 220 MPa, T = 50 °C, t = 106 min for HHP, and a 7 mm probe with 0.5 cycles (batch) for US treatment.

US treatment is recommended over thermal processing owing to the convenience, shorter processing times, and less quality loss. Likewise, HHP treatment was shorter and with lower HMF values than thermal processing. In conclusion, ultrasound and HHP are both potential alternatives to thermal processing for liquefaction of honey crystals.

Tuesday, October 24, 2017

Propolis, Honey Component May Help Treat Parkinson's Disease

Protective role of chrysin on 6-hydroxydopamine-induced neurodegeneration a mouse model of Parkinson's disease: Involvement of neuroinflammation and neurotrophins

Chem Biol Interact. 2017 Oct 17. pii: S0009-2797(17)30601-4

Chrysin is a natural flavonoid which is found in bee propolis, honey and various plants, and neuroprotective effect of chrysin in mice was previously demonstrated by our group. Neuroinflammation, neurotrophic factors and neuronal recovery factors associated with the neuroprotective effect of this flavonoid require further investigations.

Thus, now we investigated the possible involvement of inflammatory cytokines, neurotrophic factors and neuronal recovery in the effect of chrysin in 6-hydroxidopamine (6-OHDA), a well-established model of Parkinson's disease, in striatum of mice. The 6-OHDA microinjection induced behavioral alterations on the rotarod test and apomorphine-induced circling behavior in mice. 6-OHDA administration elevated levels of tumor necrosis factor-α, interferon-gamma, interleukin-1β, interleukin-2, interleukin-6 and nuclear factor-kappa B and decreased the interleukin-10 levels, total reactive antioxidant potential and total antioxidant reactivity in striatum, as well as, modified the calcium-binding protein B (S100B), brain-derived neurotrophic factor, nerve growth factor and glial cell line-derived neurotrophic factor levels. The intrastriatal injection of 6-OHDA also induced an decrease of dopamine, 3,4-dihydroxyphenylacetic acid, homovanylic acid levels and tyrosine hydroxylase content. Oral treatment with chrysin (10 mg/kg, 28 days), culminated with the prevention of these alterations occasioned by 6-OHDA.

These results corroborated with the neuroprotective effect of chrysin in the treatment of Parkinson's disease and, indicated the mechanism involved throught the inflammatory cytokines, neurotrophic factors and recovery of dopaminergic neurons in striatum.

Monday, October 23, 2017

Propolis Can Be Used as a Natural Additive Agent in Orange Juice or Other Fruit Juices

Preservation of orange juice using propolis

J Food Sci Technol. 2017 Oct;54(11):3375-3383

Orange juice is one of the most popular and the most consumed fruit juices all over the world, especially in Europe and the chemical food preservatives, such as sodium benzoate, potassium sorbate and their mixtures, have long been used in orange juice sold on the market. Excessive consumption of these preservatives may be hazardous to human health. Propolis, composed of resins collected from plant buds and exudates and mixed with salivary gland secretions and beeswax by honey bee workers, has been used as a human medicine and natural food preservative.

We hypothesis that propolis, without alcohol, can serve as an alternative and non-synthetic preservative of orange juice. In this study, the preservative effect of propolis emulsion on orange juice was determined up to 35 days. Propolis emulsion (0.02 g/mL propolis, 12 mL), emulsion control (12 mL containing Tween-80, hydrophilic phospholipid and polyethylene glycol 400), sodium benzoate (0.4 g) and potassium sorbate (0.4 g) was each added to 388, 388, 400 and 400 mL orange juice respectively.

Propolis emulsion showed significant inhibition of bacteria growth and l-ascorbic acid degradation. Orange juice pH value, titratable acidity, total phenolic content, color and antioxidant capacity were effectively maintained by propolis emulsion. A control solution with all the same emulsifying agents without propolis did not show these properties.

It was concluded that propolis can be used as a natural additive agent in orange juice or other fruit juices as an alternative to chemical preservatives.

Sunday, October 22, 2017

Propolis, Royal Jelly, and Bee Venom May Help Treat High Blood Pressure

Anti-hypertensive and cardioprotective effects of a novel apitherapy formulation via upregulation of peroxisome proliferator-activated receptor-α and -γ in spontaneous hypertensive rats

Saudi Journal of Biological Sciences

Available online 10 October 2017

Ventricular remodeling is associated with many heart diseases, and ventricular remodeling induced by hypertension can be fatal independent of hypertension. In this study, we prepared a novel apitherapy formulation, designated Bao-Yuan-Ling (BYL), which contained propolis, royal jelly, and bee venom, to treat spontaneous hypertensive rats (SHRs). We then evaluated the pharmacology of BYL and the potential mechanisms through which BYL affects hypertension and ventricular remodeling.

We found that BYL treatment could reduce blood pressure in SHRs. Thereafter, we found that BYL treatment reduced serum levels of angiotensin II, endothelin 1, and transforming growth factor-β and improved the myocardial structure. Moreover, the results of quantitative real-time polymerase chain reaction indicated that BYL treatment could upregulate the mRNA expression of peroxisome proliferator-activated receptor (PPAR)-α and PPAR-γ.

Thus, we could conclude that BYL had hypotensive and cardioprotective effects in SHRs, potentially through improvement of myocardial energy metabolism.

Saturday, October 21, 2017

Propolis Solution Helps Treat Chronic Periodontitis

One-stage Full Mouth Disinfection Using 20% Propolis Hydroalcoholic Solution: A Clinico-microbiologic Study

Contemp Clin Dent. 2017 Jul-Sep;8(3):416-420

BACKGROUND:

Propolis is a resinous substance produced by honeybees which has many therapeutic properties because of its unique composition. It has been widely used since many years for different medicinal purposes.

AIM:

The aim of this study was to investigate the effects of one-stage full mouth disinfection (OSFMD) using 20% propolis hydroalcoholic solution in chronic periodontitis patients.

MATERIALS AND METHODS:

Thirty patients diagnosed with chronic periodontitis and presenting three or more nonadjacent teeth with deep pockets were selected for the study. Clinical parameters including gingival index, plaque index, bleeding on probing, probing pocket depth, and clinical attachment level were recorded at baseline in all the patients followed by subgingival plaque sampling. All the thirty patients were randomly allocated into two groups; 15 patients (control group) were subjected to scaling and root planning (SRP) alone, and in remaining 15 patients (test group), SRP was done followed by OSFMD using 20% propolis hydroalcoholic solution after 24 h. All the patients were kept at periodic recall, and clinical and microbiological parameters were again taken at 4 weeks and 12 weeks.

RESULTS:

There was a significant improvement for all the clinical parameters, with higher probing depth reduction and attachment gain in the test group when compared to the control group. Furthermore, the microbiological counts of the periodontopathogens were found to decrease considerably more in the test group.

CONCLUSION:

SRP followed by OSFMD with propolis extract after 24 h was more effective than SRP alone in chronic periodontitis patients.

Friday, October 20, 2017

Medical-Grade Honey Dressing Use in Developing Countries

Adv Skin Wound Care. 2017 Nov;30(11):1-3

Compared with other medical honeys, SurgihoneyRO (H&R Healthcare Ltd, Southmoor, Abingdon, United Kingdom), a bioengineered medical-grade honey, delivers low concentrations of reactive oxygen to wounds over a sustained period.

This article describes how one provider, Dr Jill Brooks, has successfully used this new antimicrobial dressing in Africa and examines the potential positive impact this dressing could have on wound care in developing countries.

Thursday, October 19, 2017

Honey Eye Drops Reduce Symptoms of Dry Eye in Contact Lens Wearers

Treatment of contact lens related dry eye with antibacterial honey

Cont Lens Anterior Eye. 2017 Oct 9. pii: S1367-0484(17)30017-6

AIM:

Contact lens induced dry eye affects approximately 50% of contact lens wearers. The aim was to assess the effects of Manuka (Leptospermum sp.) honey eye drops (Optimel, Melcare, Australia) on dry eye in contact lens wearers. The safety of the honey eye drops in contact lens wear and contact lens wearers' compliance were also evaluated.

DESIGN:

Prospective, randomised, cross over study, examiner masked, pilot treatment trial.

METHODS:

Twenty-four participants aged 20 to 55 years with contact lens related dry eye were recruited and randomised to two treatment groups; 20 completed the study. One group used Optimel eye drops twice a day for two weeks followed by conventional lubricant (Systane Ultra, Alcon) therapy for two weeks; the other group completed the treatments in the reverse order. Before and after each treatment dry eye symptomology, ocular surface inflammation, and tear quantity and quality were assessed. Participants completed a daily log detailing their usage of treatments and any issues.

RESULTS:

Dry eye symptoms improved significantly after Optimel treatment. Patients with more severe symptoms at baseline showed a greater improvement in symptoms. No significant differences were observed in the objective signs of dry eye; presumably because of the short treatment duration. Seventy-five% of contact lens wearers reported good adherence to Optimel treatment and 95% reported no issues using this product.

CONCLUSIONS:

Optimel Eye Drops reduce the symptoms of dry eye in contact lens wearers and are safe to use. A longer treatment period to assess the effect on clinical signs of dry eye is required.

Wednesday, October 18, 2017

New Findings on Biological Actions and Clinical Applications of Royal Jelly: A Review

J Diet Suppl. 2017 Oct 13:1-19

Royal jelly (RJ) is a natural bee product with great potential for use in medicine. The chemical composition of RJ indicates the presence of various bioactive substances including 10-hydroxydecanoic acid and 24-methylenecholesterol. In addition, a number of biological and pharmacological activities of RJ have been documented.

The aim of this study was to review the biological and medical effects of RJ. The search was conducted in articles from electronic and scientific literature databases such as Pub Med, Science Direct, Scopus, Medline, and ISI Web of Science published from 1990 to 2017 using keywords of pharmacological, biological, and clinical effects and royal jelly. Data were chosen after the primary survey of all abstracts and selected full articles. Comparison among related data was done by the authors. Literature has shown that RJ possesses many beneficial effects on biological systems. For example, the therapeutic uses of RJ have been reported in several diseases such as hypercholesterolemia, diabetes, hypertension, and cancers. It was also found to possess neurotrophic, hypotensive, immunomodulatory, antimicrobial, antioxidant, antidiabetic, antihypercholesterolemic, antitumor, and anti-inflammatory effects.

Owing to the broad spectrum of biological effects and valuable clinical trials, evaluating the beneficial pharmaceutical effects of RJ in animal and human models seems to be important.

Tuesday, October 17, 2017

Research Project Looks at Anticancer Effect of Manuka and Strawberry Tree Honeys

Evaluation of the anticancer potential of Manuka and strawberry tree honey on a 3D model of colon cancer cells

Università Politecnica delle Marche
Italy
October 16 2017

The research project has the aim to evaluate in vitro the possible anticancer effect of two different kind of honey (Manuka and Strawberry tree honeys) in a 3D model of colon cancer cells. There should be evaluated markers of cytotoxicity, apoptosis, cell proliferation, cell migration and of cell metabolism; further studies will regards the role played by oxidative stress with special focus on the molecular mechanisms involved.

Monday, October 16, 2017

Lip Balm Containing Propolis Better Than Aciclovir Cream in Treating Cold Sores

Comparative Study with a Lip Balm Containing Propolis Special Extract GH 2002 0,5 % vs. Aciclovir Cream 5 % in Patients with Herpes labialis in the Papular / Erythematous stage. A Single-blind, Randomized Two-arm Study

Current Therapeutic Research

Available online 14 October 2017

Background and Objectives

This controlled single-blind trial compared the efficacy of a lip balm with propolis special extract GH 2002 at a concentration of 0.5 % in the treatment of episodes of Herpes labialis with that of aciclovir 5% cream.

Patients and Methods

Patients in the erythematous/papular stage were randomized to two groups: 189 patients were treated with propolis cream, 190 patients with aciclovir (ITT population). Application was five times daily. The primary parameter was the difference in median time to complete encrustation or epithelization of lesions. Secondary parameters were the development of typical Herpes symptoms (pain, burning and itching, tension and swelling), the global assessment of efficacy, and the safety of application.

Results

The predefined clinical situation was reached after a median of four days with propolis and after five days with aciclovir (p < 0.0001). Significant differences in favor of the study preparation were also found with all secondary parameters and symptoms. No allergic reactions, local irritations or other adverse events were observed.

Conclusions

Propolis GH 2002 extract lip balm 0.5 % was found superior in the treatment of episodes of Herpes labialis over aciclovir cream 5 % in patients in the papular/erythematous phase upon inclusion.

Sunday, October 15, 2017

Pollen Diversity of Bee Bread Is Linked to Its Nutrient Content

Nutritional composition of honey bee food stores vary with floral composition

Oecologia, First Online: 14 October 2017

Sufficiently diverse and abundant resources are essential for generalist consumers, and form an important part of a suite of conservation strategies for pollinators. Honey bees are generalist foragers and are dependent on diverse forage to adequately meet their nutritional needs. Through analysis of stored pollen (bee bread) samples obtained from 26 honey bee (Apis mellifera L.) hives across NW-England, we quantified bee bread nutritional content and the plant species that produced these stores from pollen.

Protein was the most abundant nutrient by mass (63%), followed by carbohydrates (26%). Protein and lipid content (but not carbohydrate) contributed significantly to ordinations of floral diversity, linking dietary quality with forage composition. DNA sequencing of the ITS2 region of the nuclear ribosomal DNA gene identified pollen from 89 distinct plant genera, with each bee bread sample containing between 6 and 35 pollen types. Dominant genera included dandelion (Taraxacum), which was positively correlated with bee bread protein content, and cherry (Prunus), which was negatively correlated with the amount of protein. In addition, proportions of amino acids (e.g. histidine and valine) varied as a function of floral species composition.

These results also quantify the effects of individual plant genera on the nutrition of honey bees. We conclude that pollens of different plants act synergistically to influence host nutrition; the pollen diversity of bee bread is linked to its nutrient content. Diverse environments compensate for the loss of individual forage plants, and diversity loss may, therefore, destabilize consumer communities due to restricted access to alternative resources.

Saturday, October 14, 2017

VIDEO: Gerard Butler Almost Had A Fatal Overdose...Of Bee Venom

By James McClure  |  Oct 13, 2017 

Gerard Butler is lucky to be alive after nearly suffering a fatal overdose...of bee venom. No, the Scottish actor wasn't partying too hard near an apiary when he decided to shoot up with stingers. He turned to venom to cope with the strain of working on the set of 'Geostorm,' which opens next weekend.

"I had a lot of inflammation," Butler told Seth Meyers yesterday. "I was hanging a lot on wires in this 65 pound space suit, and that's fine for a couple hours, but after five weeks, you're hurting."

So he turned to his nutritionist, who recommended taking bee venom, which supposedly has anti-inflammatory compounds that could've helped Butler battle through the gruelling shoot if it'd been injected properly. But the bee-venom dealer that he flew in wasn't very good at his job. And yes, Butler realizes how sketchy this whole situation sounds in retrospect...

Friday, October 13, 2017

Beeswax Helps Treat Burns

The effect of a beeswax, olive oil and Alkanna tinctoria (L.) Tausch mixture on burn injuries: An experimental study with a control group

Complement Ther Med. 2017 Oct;34:66-73

OBJECTIVES:

This study was planned to investigate the effect of a mixture of beeswax, olive oil and A. Tinctoria (L.) Tausch on burn wounds to determine the impact on burn healing, pain during dressing changes and duration of hospital stay.

METHODS:

The study was conducted between May 2014 and August 2015 in the Burn Unit of Ataturk University Research Hospital. The sample of this experimental study consisted of 64 patients (31 experimental group and 33 control group) who met its inclusion criteria. While the specially prepared dressing material was applied to the experimental group, the control group was administered the clinic's routine dressing. The injuries were photographed before each dressing. Each picture was uploaded to a computer for measurement with ImageJ software...

When a beeswax, olive oil and A. tinctoria (L.) Tausch mixture was applied to second degree burns, this accelerated epithelization, reduced the pain experienced during dressing changes and shortened the hospital stay durations of the patients.

Thursday, October 12, 2017

Honey Helps Treat Contact Lens Induced Dry Eye

Treatment of contact lens related dry eye with antibacterial honey

Contact Lens and Anterior Eye

Available online 9 October 2017

Aim

Contact lens induced dry eye affects approximately 50% of contact lens wearers. The aim was to assess the effects of Manuka (Leptospermum sp.) honey eye drops (Optimel, Melcare, Australia) on dry eye in contact lens wearers. The safety of the honey eye drops in contact lens wear and contact lens wearers’ compliance were also evaluated.

Design

Prospective, randomised, cross over study, examiner masked, pilot treatment trial.

Methods

Twenty-four participants aged 20 to 55 years with contact lens related dry eye were recruited and randomised to two treatment groups; 20 completed the study. One group used Optimel eye drops twice a day for two weeks followed by conventional lubricant (Systane Ultra, Alcon) therapy for two weeks; the other group completed the treatments in the reverse order. Before and after each treatment dry eye symptomology, ocular surface inflammation, and tear quantity and quality were assessed. Participants completed a daily log detailing their usage of treatments and any issues.

Results

Dry eye symptoms improved significantly after Optimel treatment. Patients with more severe symptoms at baseline showed a greater improvement in symptoms. No significant differences were observed in the objective signs of dry eye; presumably because of the short treatment duration. Seventy-five% of contact lens wearers reported good adherence to Optimel treatment and 95% reported no issues using this product.

Conclusions

Optimel Eye Drops reduce the symptoms of dry eye in contact lens wearers and are safe to use. A longer treatment period to assess the effect on clinical signs of dry eye is required.

Wednesday, October 11, 2017

Propolis May Help Cure nail Fungus

Antibiofilm activity of propolis extract on Fusarium species from onychomycosis

Future Microbiol. 2017 Oct 4

AIM:

The present study evaluated the capacity of three species of Fusarium isolated from onychomycosis to form biofilms and the antibiofilm effect of propolis extract on these biofilms.

MATERIALS & METHODS:

The biofilms and antibiofilm effects were evaluated by quantifying the colony-forming units, mitochondrial metabolic activity assays, total biomass by crystal violet staining and scanning electron microscopy.

RESULTS:

Propolis extract demonstrated significant antibiofilm efficiency on Fusarium spp. isolates and reduced F. solani, F. oxysporum and F. subglutinans mature biofilms.

CONCLUSION:

Propolis extract can be an alternative topical treatment of onychomycosis caused by Fusarium spp.

Tuesday, October 10, 2017

Propolis Boosts Immunity

Propolis supplementation attenuates the negative effects of oxidative stress induced by paraquat injection on productive performance and immune function in turkey poults

Poultry Science
Published: 05 October 2017 

Paraquat (PQ) is used as a herbicide in agriculture and causes oxidative and inflammatory damage to animal tissues. The current study was conducted to investigate the positive effects of dietary propolis (PR), as a potent naturally produced antioxidant, on growth performance and immune function of turkey poults exposed to oxidative stress induced by PQ injection.

Native male turkey poults (n = 120, 49-d-old) were randomly assigned into 4 groups: poults received a basal diet with a daily subcutaneous PQ injection of 5 mg/kg BW for 7 consecutive days (PQ group), an experimental diet containing 1 g/kg PR with a daily subcutaneous PQ injection for 7 days (PR+PQ group), or received the experimental PR diet with a daily subcutaneous injection of 0.5 mL sterile saline for 7 days (PR group); while the control poults received a basal diet with a daily subcutaneous saline injection for 7 consecutive days (C group). The productive performance in the PQ group showed a significant (P < 0.05) reduction in the weight gain (WG) and feed intake (FI), and impaired feed conversion ratio (FCR). Propolis supplementation in the PR+PQ group significantly ameliorated the PQ effects on WG and FCR. Turkey poults of the PQ and PR+PQ groups had a significant augmentation in the blood malondialdehyde (MDA), tumor necrosis factor-α (TNFα), and corticosterone levels, and in contrast, a significant reduction in the triiodothyronine (T3), when compared to the C group.

While propolis significantly reduced the MDA and corticosterone, and increased the T3 levels in the PR+PQ group compared to the PQ group. Furthermore, the dietary PR supplementation significantly limited the PQ-suppressive effects on cell- and humoral-mediated immunity and lymphocyte proliferation of turkey poults. In addition, propolis supplementation in the PR and PR+PQ groups markedly reversed the PQ-induced DNA fragmentation and heat shock protein 70 (Hsp70) over-expression in blood cells.

It can be concluded that PR could improve turkey immunity and performance, particularly under inflammation and oxidative stress induced by PQ exposure.

Monday, October 09, 2017

Manuka Honey May Be Effective in Treating Atopic Dermatitis Lesions


Manuka honey tested as AD treatment
Pilot study shows evidence of healing in atopic dermatitis

Dermatology Times, October 06, 2017

An open-label, pilot study has found that the topical application of manuka honey may be effective in treating atopic dermatitis lesions.

Abdullah A. Alangari M.D., the study’s lead author and an allergist at King Saud University in Saudi Arabia, says he was prompted to investigate the impact of honey after receiving anecdotal reports from patients saying they benefited from using honey to treat atopic dermatitis lesions. The study appears in a recent issue of Immunity, Inflammation and Disease.

Honey is well-recognized for its medicinal qualities and is currently being employed in wound care and as a burn treatment. Other studies have shown that it can provide antibiotic resistance to specific strains of bacteria. It's health properties are continually under study throughout the world.

In this study, investigators recruited 16 individuals (8 female, mean age 33), but two withdrew due to worsening symptoms. “We asked patients with bilateral atopic dermatitis lesions to place honey topically on one site overnight and leave the contralateral site untreated. We noted that on average the lesions treated with honey improved more than lesions that were untreated,” he said...

Sunday, October 08, 2017

Is the buzz around honey water here to stay?

Verdict, 10/6/2017

The latest addition to the list of wonder ingredients — honey — is being used for health, beauty, and even sport and as an alternative to refined sugar.

In the Venn diagram of health, beauty and sports trends, honey is firmly in the centre as a powerhouse of an ingredient.

Saturday, October 07, 2017

Royal Jelly May Help Treat Milk Allergy

Preventive effects of royal jelly against anaphylactic response in a murine model of cow's milk allergy

Pharm Biol. 2017 Dec;55(1):2145-2152

CONTEXT:

Royal jelly (RJ) has long been used to promote human health.

OBJECTIVE:

The current study investigated the preventive effects of RJ against the development of a systemic and intestinal immune response in mice allergic to cow's milk proteins.

MATERIALS AND METHODS:

Balb/c mice treated orally for seven days with RJ at doses of 0.5, 1 and 1.5 g/kg were sensitized intraperitoneally with β-lactoglobulin (β-Lg). Serum IgG and IgE anti-β-Lg were determined by an enzyme-linked immunosorbent assay (ELISA). Plasma histamine levels, symptom scores and body temperature were determined after in vivo challenge to β-Lg. Jejunums were used for assessment of local anaphylactic responses by an ex vivo study in Ussing chambers and morphologic changes by histological analysis.

RESULTS:

RJ significantly decreased serum IgG (31.15-43.78%) and IgE (64.28-66.6%) anti-β-Lg and effectively reduced plasma histamine level (66.62-67.36%) (p < 0.001) at all the doses tested. Additionally, no clinical symptoms or body temperature drops were observed in RJ-pretreated mice. Interestingly, RJ significantly reduced (p < 0.001) intestinal dysfunction by abolishing the secretory response (70.73-72.23%) induced by sensitization and prevented length aberrations of jejunal villi by 44.32-59.01% (p < 0.001).

DISCUSSION AND CONCLUSIONS:

We speculate that using RJ may help prevent systemic and anaphylactic response in allergic mice. These effects may be related to its inhibitory effects on the degranulation of mast cells.

Friday, October 06, 2017

Honey Better than Phenytoin for Healing Episiotomy Wounds

Comparison of honey and phenytoin (PHT) cream effects on intensity of pain and episiotomy wound healing in nulliparous women

J Complement Integr Med. 2017 Oct 5

Background

This study investigates and compares the effect of phenytoin and honey cream on intensity of pain and episiotomy wound healing in nulliparous women.

Methods

This research was conducted by double-blinded randomized clinical trial method on 120 nulliparous women in three groups of phenytoin, honey and placebo. After delivery and episiotomy, mothers used a knuckle of the prescribed creams on their episiotomy area, every night until 10-night. Evaluation of wound healing using REEDA scale and pain intensity with numerical rating scale of pain took place within the first 24 h and after 7 and 14 days of delivery.

Results

Results showed significant differences between healing scores of the three groups for the seventh day after delivery. Healing score in the honey group was lower than that in placebo group. On the fourteenth day after delivery, the healing scores showed no significant differences between the three groups. Measuring pain intensity did not show any significant difference in the three groups after 7 and 14 days of delivery.

Conclusions

Both honey and phenytoin led to episiotomy wound healing; however, honey caused the wound healing better than the phenytoin. Honey and phenytoin did not reduce episiotomy pain.